57) Te Zhang, Oguzhan Beytullahoglu, Rima Tulaiha, Amanda Luvisotto, Aileen Szczepanski, Natsumi Tsuboyama, Zibo Zhao, Lu Wang*. An epigenetic pathway regulates MHC-II expression and function in B cell lymphoma models. Journal of Clinical Investigation. 2025 Jan 16;135(2):e179703 (*corresponding author)
56) Aileen Patricia Szczepanski, Natsumi Tsuboyama, Huijue Lyu, Ping Wang, Oguzhan Beytullahoglu, Te Zhang, Benjamin D Singer, Feng Yue, Zibo Zhao*, Lu Wang*. A SWI/SNF-dependent transcriptional regulation mediated by POU2AF2/C11orf53 at enhancer. Nature Communications. Volume 15, Article number: 2067 (2024). (*co-corresponding author)
55) Bin Zheng, Sarah Ruth Gold, Marta Iwanaszko, Benjamin Charles Howard, Lu Wang*, and Ali Shilatifard*. Distinct layers of BRD4-PTEFb reveal bromodomain-independent function in transcriptional regulation. Molecular Cell. 2023 Jul 10; S1097-2765(23)00508-7. (*co-corresponding author)
54) Omar Bushara, James Wester, Danielle Jacobsen, Leyu Sun, Samuel Weinberg, Juehua Gao, Lawrence J Jennings, Lu Wang, Shannon M Lauberth, Feng Yue, Jie Liao, Guang-Yu Yang. Clinical and Histopathologic Characterization of SETD2-Mutated Colorectal Cancer. Hum Pathol. 2022 Dec 8; S0046-8177(22)00279-9.
53) Aileen Patricia Szczepanski, Natsumi Tsuboyama, Jun Watanabe, Rintaro Hashizume, Zibo Zhao*, Lu Wang*. POU2AF2/C11orf53 functions as a coactivator of POU2F3 by maintaining chromatin accessibility and enhancer activity. Science Advances. 2022 Oct 7;8(40):eabq2403. *co-corresponding author
52) Zibo Zhao, Emily Jane Rendleman, Aileen Patricia Szczepanski, Marc Alard Morgan, Lu Wang*, Ali Shilatifard*. CARM1-mediated methylation of ASXL2 impairs tumor suppressive function of MLL3/COMPASS. Science Advances. 2022 Oct 7;8(40): eadd3339. *co-corresponding author
51) Andrea Piunti, Khyati Meghani, Yanni Yu, A Gordon Robertson, Joseph R Podojil, Kimberly A McLaughlin, Zonghao You, Damiano Fantini, MingYi Chiang, Yi Luo, Lu Wang, Nathan Heyen, Jun Qian, Stephen D Miller, Ali Shilatifard, Joshua J Meeks. Immune activation is essential for the antitumor activity of EZH2 inhibition in urothelial carcinoma. Science Advances. 2022 Oct 7;8(40): eabo8043
50) Natsumi Tsuboyama, Aileen Patricia Szczepanski, Zibo Zhao, Lu Wang*. MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer. Genome Biology. 2022 Sep 30;23(1):206. *corresponding author
49) Natsumi Tsuboyama, Ru Wang, Aileen Patricia Szczepanski, Huanhuan Chen, Zibo Zhao, Lei Shi*, Lu Wang*. Therapeutic targeting of BAP1/ASXL3 sub-complex in ASCL1-dependent small cell lung cancer. Oncogene. 2022 Feb 22. *co-corresponding author
48) Edgar Gonzalez-Buendia, Junfei Zhao, Lu Wang, Subhas Mukherjee, Daniel Zhang, Victor A. Arrieta, Eric Feldstein, Joshua Robert Kane, Seong Jae Kang, Catalina Lee-Chang, Aayushi Mahajan, Li Chen, Ronald Realubit, Charles Karan, Lisa Magnusson, Craig Horbinski, Stacy A. Marshall, Jann N. Sarkaria, Ahmed Mohyeldin, Ichiro Nakano, Mukesh Bansal, Charles D. James, Daniel J. Brat, Atique Ahmed, Peter Canoll, Raul Rabadan, Ali Shilatifard and Adam M. Sonabend. TOP2B enzymatic activity on promoters and introns modulates multiple oncogenes in human gliomas. Clinical Cancer Research. 2021 Aug 25. Published Online First
47) Zibo Zhao, Aileen P Szczepanski, Natsumi Tsuboyama, Hiam Abdala-Valencia, Young Ah Goo, Benjamin D Singer, Elizabeth T Bartom, Feng Yue, Lu Wang*. PAX9 determines epigenetic state transition and cell fate in cancer. Cancer Research. 2021 Sep 15;81(18):4696-4708. *corresponding author
46) Lu Wang, Noah Warren Birch, Zibo Zhao, Carson Meredith Nestler, Alexander Kazmer, Anthony Shilati, Alisha Blake, Patrick Alexander Ozark, Emily Jane Rendleman, Didi Zha, Caila Ann Ryan, Marc Alard Jonathan Morgan, Ali Shilatifard. Epigenetic targeted therapy of stabilized BAP1 in ASXL1 gain-of-function mutated leukemia. Nature Cancer. 2021 May (5), 515-526.
Highlighted by Nature Cancer, Epigenetic Achilles’ heel of AML.
45) Tejaswi Iyyanki, Baozhen Zhang, Qixuan Wang, Ye Hou, Qiushi Jin, Jie Xu, Hongbo Yang, Tingting Liu, Xiaotao Wang, Fan Song, Yu Luan, Hironobu Yamashita, Ruby Chien, Huijue Lyu, Lijun Zhang, Lu Wang, Joshua Warrick, Jay D Raman, Joshua J Meeks, David J DeGraff, Feng Yue. Subtype-associated epigenomic landscape and 3D genome structure in bladder cancer. Genome Biology. 2021 Apr 15;22(1):105.
44) Yang Yi, Yanqiang Li, Qingshu Meng, Qiaqia Li, Fuxi Li, Bing Lu, Jiangchuan Shen, Ladan Fazli, Dongyu Zhao, Chao Li, Weihua Jiang, Rui Wang, Qipeng Liu, Aileen Szczepanski, Qianru Li, Wei Qin, Adam B Weiner, Tamara L Lotan, Zhe Ji, Sundeep Kalantry, Lu Wang, Edward M Schaeffer, Hengyao Niu, Xuesen Dong, Wei Zhao, Kaifu Chen, Qi Cao. A PRC2-independent function for EZH2 in regulating rRNA 2′-O methylation and IRES-dependent translation. Nature Cell Biology. 2021 Apr 1. doi: 10.1038/s41556-021-00653-6.
43) Aileen Patricia Szczepanski, Lu Wang*. Emerging multifaceted roles of BAP1 complexes in biological processes. Cell Death Discovery. 2021 Jan 22;7(1):20. *corresponding author
42) Kaixiang Cao, Michal Ugarenko, Patrick A Ozark, Juan Wang, Stacy A Marshall, Emily J Rendleman, Kaiwei Liang, Lu Wang, Lihua Zou, Edwin R Smith, Feng Yue, Ali Shilatifard. DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation. Proceedings of the National Academy of Sciences. 2020 Nov 3;117(44):27365-27373.
41) Ryan Rickels, Lu Wang, Marta Iwanaszko, Patrick A Ozark, Marc A Morgan, Andrea Piunti, Natalia Khalatyan, Shimaa HA Soliman, Emily J Rendleman, Jeffrey N Savas, Edwin R Smith, Ali Shilatifard. A small UTX stabilization domain of Trr is conserved within mammalian MLL3-4/COMPASS and is sufficient to rescue loss of viability in null animals. Genes & Development. 2020 Oct 8;34(21-22):1493-502.
40) Aileen Patricia Szczepanski, Zibo Zhao, Tori Sosnowski, Young Ah Goo, Elizabeth Thomas Bartom, Lu Wang*. ASXL3 bridges BRD4 to BAP1 complex and governs enhancer activity in small cell lung cancer. Genome Medicine 2020 Jul 15; 12(1):63. *corresponding author
39) Christie C Sze, Patrick A Ozark, Kaixiang Cao, Michal Ugarenko, Siddhartha Das, Lu Wang, Stacy A Marshall, Emily J Rendleman, Caila A Ryan, Didi Zha, Delphine Douillet, Fei Xavier Chen, Ali Shilatifard. Coordinated regulation of cellular identity–associated H3K4me3 breadth by the COMPASS family. Science Advances 2020 Jun 24;6(26):eaaz4764
Lu Wang established his lab at Northwestern University (2019.9).
38) Zibo Zhao, Lu Wang, Elizabeth Bartom, Stacy Marshall, Emily Rendleman, Caila Ryan, Anthony Shilati, Jeffrey Savas, Navdeep Chandel, Ali Shilatifard. β-Catenin/Tcf7l2–dependent transcriptional regulation of GLUT1 gene expression by Zic family proteins in colon cancer. Science Advances 2019 Jul 31;5(7):eaax0698
37) Joshua Pan, Zachary M. McKenzie, Andrew R. D’Avino, Nazar Mashtalir, Caleb A. Lareau, Roodolph St. Pierre, Lu Wang, Ali Shilatifard, and Cigall Kadoch. The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity-independent genomic targeting. Nature genetics 2019 Apr;51(4):618-626
36) Lu Wang, Ali Shilatifard. UTX mutations in human cancer. Cancer cell 2019 Feb 11;35(2):168-176.
35) Lu Wang, Patrick A. Ozark, Edwin R. Smith, Zibo Zhao, Stacy A. Marshall, Emily J. Rendleman, Andrea Piunti, Caila Ryan, Anna L. Whelan, Kathryn A. Helmin, Marc Alard Morgan, Lihua Zou, Benjamin D. Singer, Ali Shilatifard. TET2 coactivates gene expression through demethylation of enhancers. Science Advances. 2018 Nov 7; 4(11), eaau6986.
34) Zibo Zhao, Lu Wang, Andrew G. Volk, Noah W. Birch, Kristen L. Stoltz, Elizabeth T. Bartom, Stacy A. Marshall, Emily J. Rendleman, Carson M. Nestler, Joseph Shilati, Gary E. Schiltz, John D. Crispino, and Ali Shilatifard. Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia. Genes & Development. Genes Dev. 2019 Jan 1; 33(1-2):61-74
33) Kaiwei Liang, Edwin R. Smith, Yuki Aoi, Kristen L. Stoltz, Hiroaki Katagi, Ashley R. Woodfin, Emily J. Rendleman, Stacy A. Marshall, David C. Murray, Lu Wang, Patrick A. Ozark, Rama K. Mishra, Rintaro Hashizume , Gary E. Schiltz, and Ali Shilatifard. Targeting Processive Transcriptional Elongation through SEC Disruption. Cell. 2018 Oct 18; 175(3):766-779
32) Jin Q, Martinez CA, Arcipowski KM, Zhu Y, Gutiérrez-Díaz BT, Wang KK, Johnson MR, Volk A, Wang F, Wu J, Grove C, Wang H, Sokirniy I, Thomas PM, Goo YA, Abshiru NA, Hijiya N, Peirs S, Vandamme N, Berx G, Goossens S, Marshall SA, Rendleman EJ, Takahashi YH, Wang L, Rawat R, Bartom ET, Collings CK, Van Vlierberghe P, Bourquin JP, Bornhauser B, Serafin V, Bresolin S, Paganin M, Accordi B, Basso G, Kelleher NL, Weinstock J, Suresh K, Crispino JD, Shilatifard A, Strikoudis A, Mantis C, Kandela I, Kelly S, Ueberheide B, Ntziachristos P. USP7 cooperates with NOTCH1 to drive the oncogenic transcriptional program in T cell leukemia. Clincal Cancer Research. 2018 Sep 17. pii: clincanres.1740.2018.
31) Lu Wang, Zibo Zhao, Patrick Alexander Ozark, Damiano Fantini, Stacy A. Marshall, Emily J. Rendleman, Kira A. Cozzolino, Nundia Louis, Xingyao He, Marc A. Morgan, Yoh-hei Takahashi, Clayton K. Collings, Edwin R. Smith, Panagiotis Ntziachristos, Jeffrey N. Savas, Lihua Zou, Rintaro Hashizume, Joshua J. Meeks, and Ali Shilatifard. Resetting the Epigenetic Balance of Polycomb and COMPASS Function at Enhancers for Cancer Therapy. Nature Medicine 2018 Jun; 24(6):758-769.
Highlighted
by Cancer Discovery, MLL3 Mutations
Disrupt COMPASS Recruitment to Enhancer Chromatin.
Highlighted
by Science Translational Medicine,
Correcting COMPASS dysfunction in cancer. Recommended to Faculty of 1000.
30) Damiano Fantini, Alexander Glaser, Kalen Rimar, Yiduo Wang, Matthew Schipma, Nobish Varghese, Alfred Rademaker, Amir Behdad, Aparna Yellapa, Yanni Yu, Christie Sze, Lu Wang, Susan Crawford, Zibo Zhao, Deqing Hu, Jonathan Licht, Clayton Collings, Elizabeth Bartom, Dan Theodorescu, and Ali Shilatifard, and Joshua Meeks. A Carcinogen-induced Mouse Model Recapitulates the Molecular Alterations of Human Muscle Invasive Bladder Cancer. Oncogene. 2018 Jan 25. doi: 10.1038/s41388-017-0099-6.
29) Ryan Rickels, Hans-Martin Herz, Christie C Sze, Kaixiang Cao, Marc A Morgan, Clayton K Collings, Maria Gause, Yoh-hei Takahashi, Lu Wang, Emily J Rendleman, Stacy A Marshall, Annika Krueger, Elizabeth T Bartom, Andrea Piunti, Edwin Smith, Nebiyu A Abshiru, Neil L Kelleher, Dale Dorsett, and Ali Shilatifard. Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability. (2017). Nature Genetics. 2017 Nov; 49(11):1647-1653.
28) Lu Wang, Clayton K. Collings, Zibo Zhao, Kira Alia Cozzolino, Quanhong Ma, Kaiwei Liang, Stacy A. Marshall, Christie C. Sze, Rintaro Hashizume, Jeffrey Nicholas Savas, Ali Shilatifard. A cytoplasmic COMPASS is necessary for cell survival and triple negative breast cancer pathogenesis by regulating the metabolic program. Genes & Development. 2017 Oct 15; 31(20):2056-2066.
27) Christie C. Sze, Kaixiang Cao, Clayton K. Collings, Stacy A. Marshall, Emily J. Rendleman, Patrick A. Ozark, Fei Xavier Chen, Marc A. Morgan, Lu Wang, and Ali Shilatifard. Histone H3K4 methylation-dependent and independent functions of Set1A/COMPASS in embryonic stem cell pluripotency and differentiation. Genes & Development. 2017 Sep 1; 31(17): 1732-1737.
26) Cao K, Collings CK, Marshall SA, Morgan MA, Rendleman EJ, Wang L, Sze CC, Sun T, Bartom ET, Shilatifard A. SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expression. Genes & Development. 2017 Apr 15; 31(8):787-801.
25) Wang J, Yunyun Z, Wang L, Chen X, Zhu Z. ABCG2 confers promotion in gastric cancer through modulating downstream CRKL in vitro combining with biostatistics mining. Oncotarget. 2017 Jan 17; 8(3):5256-5267.
24) Zibo Zhao, Lu Wang, Ikyon Kim, Renxiang Tan, Wei Xu. Reciprocal regulation of ERα and ERβ stability and activity by Diptoindonesin G. Chemistry & Biology. 2015 Dec 17; 22(12):1608-21.
23) Lu Wang, Hao Zeng, Qiang Wang, Zibo Zhao, Thomas G. Boyer, Xiuwu Bian, Wei Xu. MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs. Science Advances. 2015 Oct 9; 1(9):e1500463
22) David Shlensky, Jennifer A Mirrielees, Zibo Zhao, Lu Wang, Aparna Mahajan, Menggang Yu, Nathan M Sherer, Lee G. Wilke, Wei Xu. Differential CARM1 isoform expression in subcellular compartments and among malignant and benign breast tumors. PloS ONE. 2015 Jun 1; 10(6):e0128143
21) Purin Charoensuksai, Peter Kuhn, Lu Wang, Nathan Sherer, Wei Xu. O-GlcNAcylation of coactivator-associated arginine methyltransferase 1 regulates its protein substrate specificity. Biochemical Journal.2015 Mar 15; 466(3):587-99.
20) Zibo Zhao, Lu Wang and Wei Xu. IL-13Rα2 mediates PNR-induced migration and metastasis in ERα- negative breast cancer. Oncogene. 2014 Apr 21. doi: 10.1038/onc.2014.53.
19) Yamei Hu, Lingxian Wang, Lu Wang, Xuefeng Wu, Xudong Wu, Yanhong Gu, Yongqian Shu, Yang Sun, Yan Shen, Qiang Xu. Preferential cytotoxicity of bortezomib towards highly malignant human liposarcoma cells via suppression of MDR1expression and function. Toxicology and Applied Pharmacology. 2015 Feb 15; 283(1):1-8
Lu Wang started a second postdoctoral training in Dr. Ali Shilatifard’s lab at Northwestern University (2015.2).
18) Wanshuai Li, Zijun Ouyang, Qi Zhang, Lu Wang, Yan Shen, Xudong Wu, Yanhong Gu, Yongqian Shu, Biao Yu, Xuefeng Wu, Yang Sun and Qiang Xu. SBF-1 exerts strong anti-cervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca2+-ATPase 2. Cell Death & Disease. 2014 Dec 18; 5: e1581.
17) Lu Wang, Wangshuai Li, Yang Yang, Yanhong Gu, Yongqian Shu, Yan Shen and Qiang Xu. High expression of sarcoplasmic/endoplasmic reticulum Ca (2+)-ATPase 2b blocks cell differentiation in human liposarcoma cells. Life Sciences. 2014 Mar 18; 99(1-2):37-43.
16) Wei Cheng, Lu Wang, Bingya Yang, Rong Zhang, Chun Yao, Liangqiang He, Zexu Liu, Pan Du, Juan Wen Huang Li, Qiang Xu, Hua Zichun. Self-renewal and Differentiation of Muscle Satellite Cells is Regulated by Fas-associated Death Domain. Journal of Biological Chemistry. 2014 Feb 21; 289 (8):5040-50
15) Lu Wang, Zibo Zhao, Mark B. Meyer, Sandeep Saha, Menggang Yu, Ailan Guo, Kari B. Wisinski, Wei Huang, Weibo Cai, J. Wesley Pike, Ming Yuan, Paul Ahlquist, Wei Xu. CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis. Cancer Cell. 2014 Jan 13; 25(1):21-36.
Previewed
in Cancer Cell, CARMA: CARM1 Methylation of SWI/SNF in Breast Cancer.
Recommended to Faculty of 1000.
14) Rong Zhang, Lu Wang, Liangqiang He, Bingya Yang, Chun Yao, Pan Du, Qiang Xu, Cheng Wei, Zi- Chun Hua. Fas-Associated Protein with Death Domain Regulates Notch Signaling during Muscle Regeneration. Cells Tissues Organs 2014; 200(3-4):253-64.
13) Tao Zhang, Wenjie Guo, Yang Yang, Wen Liu, Lele Guo, Yanhong Gu, Yongqian Shu, Lu Wang, Xuefeng Wu, Zichun Hua, Yuehai Ke, Yang Sun, Yan Shen. Loss of SHP-2 activity in CD4+ T cells promotes melanoma progression and metastasis. Scientific Reports. 2013 Oct 3; 3:2845
12) Zibo Zhao, Lu Wang, Zhi Wen, Serife Ayaz-guner, Yidan Wang, Paul Ahlquist, Wei Xu. Systematic analyses of the cytotoxic effects of 11a, a putative synthetic agonist of photoreceptor-specific nuclear receptor (PNR), in cancer cell lines. PLoS ONE. 2013 Sep 16; 8(9):e75198.
11) Lu Wang, Purin Charoensuksai, Nikole J. Watson, Xing Wang, Zibo Zhao, Carlos G. Coriano, Leslie Kerr, Wei Xu. CARM1 automethylation is controlled at the level of alternative splicing. Nucleic Acids Research. 2013; 1-11.
10) Wanshuai Li, Yang Yang, Zijun Ouyang, Qi Zhang, Lu Wang, Feifei Tao, Q. Xu and Yang Sun. Xiao-Ai-Ping, a TCM injection, enhances the anti-growth effects of cisplatin on Lewis lung cancer cells through promoting the infiltration and functions of CD8+ T cells. Evidence-Based Complementary and Alternative Medicine. 2013; 2013:879512.
9) Xianying Fang, Wei Chen, Junting Fan, Song Ran, Lu Wang, Yanhong Gu, Guangzhi Zeng, Yan Shen, Xuefeng Wu, Ninghua Tan, Yang Sun, and Qiang Xu. Plant cyclopeptide RA-V kills human breast cancer cells by inducing mitochondria-mediated apoptosis through blocking PDK1-AKT interaction. Toxicology and Applied Pharmacology. 2013 Feb 15; 267(1):95-103.
8) Wanshuai Li, Ran Song, Xianying Fang, Lu Wang, Biao Yu, Yang Sun, and Qiang Xu. SBF-1, a synthetic steroidal glycoside, inhibits melanoma growth and metastasis through blocking interaction between PDK1 and AKT3. Biochemical Pharmacology. 2012 Jul 15; 84(2):172-81.
7) Hailiang Liu, Rui Xu, Lili Feng, Wenjie Guo, Ning Cao, Chen Qian, Peng Teng, Lu Wang, Jianxin Li, Yang Sun, Yan Shen, Qiang Xu. A novel chromone derivative with anti-inflammatory property via inhibition of ROS-dependent activation of TRAF6-ASK1-p38 pathway. PLoS ONE 2012; 7(8):e37168.
6) Shi L, Wang L, Wang Z, Zhu HL, Song Q. Synthesis of novel cinnamanilides as potential immunosuppressive agents. European Journal of Medicinal Chemistry. 2012 Jan; 47(1):585-93.
5) Jianliang Xu, Shaoxian Cao, Lu Wang, Rui Xu, Gong Chen and Qiang Xu. VEGF promotes the transcription of human PRL-3 gene in HUVEC through transcription factor MEF2C. PLoS ONE. 2011; 6(11):e27165.
Recommended to Faculty of 1000.
4) Lu Wang, Lingxian Wang, Yanhong Gu, Yongqian Shu, Yan Shen, Qiang Xu. Integrin a6high Cell Population Functions as an Initiator in Tumorigenesis and Relapse of Human Liposarcoma. Molecular Cancer Therapeutics. 2011 Dec; 10(12):2276-86.
Lu Wang graduated from Nanjing University and joint Dr. Wei Xu’s lab at UW Madison (2011.8).
3) Ying L. Zhang, Jie Zhang, Nan Jiang, Yan H. Lu, Lu Wang, Su H. Xu, Wei Wang, Gao F. Zhang, QiangXu, Hui M. Ge, Jing Ma, Yong C. Song, and Ren X. Tan. Immunosuppressive Polyketides from Mantis-Associated Daldinia Eschscholzii. Journal of American Chemical Society. 2011 Apr 20; 133(15):5931-40.
2) Lu Wang, Lingxian Wang, Ran Song, Yan Shen, Yang Sun, Yanhong Gu, Yongqian Shu, and Qiang Xu. Targeting sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2 by Curcumin Induces ER Stress-associated Apoptosis for Treating Human Liposarcoma. Molecular Cancer Therapeutics. 2011 Mar; 10(3):461-71.
1) Lu Wang, Yan Shen, Ran Song, Yang Sun, Jianliang Xu, and Qiang Xu. An Anticancer Effect of Curcumin Mediated by Down-Regulating Phosphatase of Regenerating Liver-3 Expression on Highly Metastatic Melanoma Cells. Molecular Pharmacology. 2009 Dec; 76(6):1238-45.
